Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate

被引：109

作者：

Zhao, H ^{[1
]}

Malhotra, SV ^{[1
]}

机构：

[1] New Jersey Inst Technol, Dept Chem & Environm Sci, Newark, NJ 07102 USA

来源：

BIOTECHNOLOGY LETTERS | 2002年 / 24卷 / 15期

关键词：

alcalase; amino acid; enantiomer; enzymatic resolution; ionic liquid;

D O I：

10.1023/A:1016205924504

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new ionic liquid, N-ethyl pyridinium trifluoroacetate, was used with a commercial protease to resolve N-acetyl amino acid esters in place of traditional organic solvents. Products with enantiomeric excess (ee) between 86-97% were obtained. These results show that with low concentration of this new ionic liquid, the enzymatic resolution can be increased considerably depending upon the substrate being used.

引用

页码：1257 / 1260

页数：4

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