V(D)J recombinational accessibility - heading in the opposite direction?

被引：3

作者：

Giallourakis, C ^{[1
]}

Alt, FW

Bassing, CH

机构：

[1] Harvard Univ, Sch Med, CBR, Inst Biomed Res, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Childrens Hosp, Howard Hughes Med Inst,Dept Genet, Boston, MA 02115 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 06期

关键词：

D O I：

10.1038/ni0604-561

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The assembly of antigen receptor genes in developing lymphocytes through V(D)J recombination is regulated through a mostly undefined but broadly relevant process referred to as 'accessibility'. New findings raise the possibility that wide-ranging, antisense transcription through unrearranged antigen receptor loci could be involved in modulating recombinational accessibility.

引用

页码：561 / 562

页数：2

共 11 条

[1] The mechanism and regulation of chromosomal V(D)J recombination [J].

Bassing, CH ;

Swat, W ;

Alt, FW .

CELL, 2002, 109 :S45-S55

[2] Antisense intergenic transcription in V(D)J recombination [J].

Bolland, DJ ;

Wood, AL ;

Johnston, CM ;

Bunting, SF ;

Morgan, G ;

Chakalova, L ;

Fraser, PJ ;

Corcoran, AE .

NATURE IMMUNOLOGY, 2004, 5 (06) :630-637

[3] Heterochromatin and epigenetic control of gene expression [J].

Grewal, SIS ;

Moazed, D .

SCIENCE, 2003, 301 (5634) :798-802

[4] Establishment and maintenance of a heterochromatin domain [J].

Hall, IM ;

Shankaranarayana, GD ;

Noma, KI ;

Ayoub, N ;

Cohen, A ;

Grewal, SIS .

SCIENCE, 2002, 297 (5590) :2232-2237

[5] Gene segment selection in V(D)J recombination: accessibility and beyond [J].

Krangel, MS .

NATURE IMMUNOLOGY, 2003, 4 (07) :624-630

[6] Increase of TCR vβ accessibility within Eβ regulatory region influences its recombination frequency but not allelic exclusion [J].

Senoo, M ;

Wang, LL ;

Suzuki, D ;

Takeda, N ;

Shinkai, Y ;

Habu, S .

JOURNAL OF IMMUNOLOGY, 2003, 171 (02) :829-835

[7] Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibility [J].

Sikes, ML ;

Meade, A ;

Tripathi, R ;

Krangel, MS ;

Oltz, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (19) :12309-12314

[8] Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement [J].

Su, IH ;

Basavaraj, A ;

Krutchinsky, AN ;

Hobert, O ;

Ullrich, A ;

Chait, BT ;

Tarakhovsky, A .

NATURE IMMUNOLOGY, 2003, 4 (02) :124-131

[9]

ten Boekel E, 1999, CURR TOP MICROBIOL, V246, P3

[10] DEVELOPMENTALLY CONTROLLED AND TISSUE-SPECIFIC EXPRESSION OF UNREARRANGED VH GENE SEGMENTS [J].

YANCOPOULOS, GD ;

ALT, FW .

CELL, 1985, 40 (02) :271-281

← 1 2 →