Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori

被引：56

作者：

Colbeck, Jeffrey C.

Hansen, Lori M.

Fong, Julie M.

Solnick, Jay V. ^{[1
]}

机构：

[1] Univ Calif Davis, Ctr Comparat Med, Dept Internal Med, Davis, CA 95616 USA

[2] Univ Calif Davis, Ctr Comparat Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 07期

关键词：

D O I：

10.1128/IAI.00485-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.

引用

页码：4375 / 4378

页数：4

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