Sesquiterpene aminoquinones, from a marine sponge, induce erythroid differentiation in human chronic myelogenous leukemia, K562 cells

被引：39

作者：

Aoki, S

Kong, D

Matsui, K

Rachmat, R

Kobayashi, M

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

[2] LIPI, Res & Dev Ctr Oceanol, Jakarta 11048, Indonesia

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 08期

关键词：

5-epi-smenospongorine; erythroid differentiation; structure-activity relationship; K562; cells; marine sponge;

D O I：

10.1248/cpb.52.935

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.

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页码：935 / 937

页数：3

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