Pathomechanisms: homeostatic chemokines in health, tissue regeneration, and progressive diseases

被引：70

作者：

Anders, Hans-Joachim ^{[1
]}

Romagnani, Paola ^{[2
]}

Mantovani, Alberto ^{[3
,4
]}

机构：

[1] Klinikum Univ, Med Klin & Poliklin 4, Nephrol Zentrum, Munich, Germany

[2] Univ Florence, Excellence Ctr Res Transfer & High Educ Dev De No, Florence, Italy

[3] IRCCS, Ist Clin Humanitas, I-20089 Rozzano, Italy

[4] Univ Milan, Dept Translat Med, I-20089 Rozzano, Italy

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 03期

基金：

欧洲研究理事会;

关键词：

tissue damage; regeneration; inflammation; malignancy; chemokine receptor; CELL-DERIVED FACTOR-1; MESENCHYMAL STEM-CELL; CXCR4 ANTAGONIST PLERIXAFOR; SECONDARY LYMPHOID ORGANS; EXPRESS FUNCTIONAL CXCR4; BREAST-CANCER METASTASIS; MYELOID PROGENITOR CELLS; POSTNATAL DENTATE GYRUS; BONE-MARROW; RECEPTOR CXCR4;

D O I：

10.1016/j.molmed.2013.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Homeostatic chemokines control stem and progenitor cell migration and activation during vasculogenesis and organ development. They orchestrate hematopoietic stem cell (HSC) homing to their bone marrow niches and direct immature lymphocytes to a series of maturation sites within lymphoid organs. Along these lines, homeostatic chemokines regulate the niches of peripheral committed progenitor cell populations for tissue renewal. These biological functions support neovascularization and wound healing, including the recruitment of endothelial and other progenitor cells from the bone marrow. Here, we summarize the roles of homeostatic chemokines, their signaling receptors, and atypical decoy receptors during homeostasis and tissue regeneration in order to better understand their pathogenic roles in disease, for example, in diabetes complications, cancer, autoimmunity, epithelial hyperplasia, or hypertrophic scarring and fibrosis.

引用

页码：154 / 165

页数：12

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