A biomolecular detection method based on charge pumping in a nanogap embedded field-effect-transistor biosensor

被引：22

作者：

Kim, Sungho ^{[1
]}

Ahn, Jae-Hyuk ^{[1
]}

Park, Tae Jung ^{[2
,3
]}

Lee, Sang Yup ^{[2
,3
,4
,5
]}

Choi, Yang-Kyu ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Div Elect Engn, Sch Elect Engn & Comp Sci, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Ctr Syst & Synthet Biotechnol, Bioproc Engn Res Ctr, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Inst BioCentury, Taejon 305701, South Korea

[4] Korea Adv Inst Sci & Technol, Dept Biol Sci, Dept Bio & Brain Engn, Taejon 305701, South Korea

[5] Korea Adv Inst Sci & Technol, Bioinformat Res Ctr, Taejon 305701, South Korea

来源：

APPLIED PHYSICS LETTERS | 2009年 / 94卷 / 24期

关键词：

bioelectric phenomena; biological techniques; diseases; field effect transistors; molecular biophysics; MOSFETS;

D O I：

10.1063/1.3148340

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

A unique direct electrical detection method of biomolecules, charge pumping, was demonstrated using a nanogap embedded field-effect-transistor (FET). With aid of a charge pumping method, sensitivity can fall below the 1 ng/ml concentration regime in antigen-antibody binding of an avian influenza case. Biomolecules immobilized in the nanogap are mainly responsible for the acute changes of the interface trap density due to modulation of the energy level of the trap. This finding is supported by a numerical simulation. The proposed detection method for biomolecules using a nanogap embedded FET represents a foundation for a chip-based biosensor capable of high sensitivity.

引用

页数：3

共 10 条

[1] LATERAL DISTRIBUTION OF HOT-CARRIER-INDUCED INTERFACE TRAPS IN MOSFETS [J].