Complement regulators and inhibitory proteins

被引：955

作者：

Zipfel, Peter F. ^{[1
,2
]}

Skerka, Christine ^{[1
]}

机构：

[1] Leibniz Inst Nat Prod Res & Infect Biol, Dept Infect Biol, D-07745 Jena, Germany

[2] Univ Jena, D-07743 Jena, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

MEMBRANE COFACTOR PROTEIN; FACTOR-H; ALTERNATIVE PATHWAY; APOPTOTIC CELLS; PATTERN-RECOGNITION; CARBOXYPEPTIDASE-N; ENDOTHELIAL-CELLS; C5A ANAPHYLATOXIN; IMMUNE-RESPONSE; PROTECTIVE ROLE;

D O I：

10.1038/nri2620

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complement system is important for cellular integrity and tissue homeostasis. Complement activation mediates the removal of microorganisms and the clearance of modified self cells, such as apoptotic cells. Complement regulators control the spontaneously activated complement cascade and any disturbances in this delicate balance can result in damage to tissues and in autoimmune disease. Therefore, insights into the mechanisms of complement regulation are crucial for understanding disease pathology and for enabling the development of diagnostic tools and therapies for complement-associated diseases.

引用

页码：729 / 740

页数：12

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