Application of high pressure, induced by water freezing, to the direct asymmetric aldol reaction

被引：49

作者：

Hayashi, Y

Tsuboi, W

Shoji, M

Suzuki, N

机构：

[1] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan

[2] RIKEN, Wako, Saitama 3510198, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 22期

关键词：

high pressure; asymmetric reaction; direct aldol reaction; organocatalyst; proline;

D O I：

10.1016/j.tetlet.2004.03.190

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High pressure, induced by water freezing, has been successfully applied to the direct catalytic asymmetric aldol reaction, in which higher yield and better enantioselectivity can be realized than in the reaction at room temperature under 0.1 M Pa. (C) 2004 Elsevier Ltd. All Lights reserved.

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收藏

页码：4353 / 4356

页数：4

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