Near Infrared Light- Triggered Drug Generation and Release from Gold Nanoparticle Carriers for Photodynamic Therapy

被引：122

作者：

Cheng, Yu ^{[1
]}

Doane, Tennyson L. ^{[1
]}

Chuang, Chi-Hung ^{[1
]}

Ziady, Assem ^{[2
]}

Burda, Clemens ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA

[2] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA

来源：

SMALL | 2014年 / 10卷 / 09期

关键词：

phototriggered release; caged drug; gold nanoparticle; photodynamic therapy; DELIVERY SYSTEMS; PHOTOSENSITIZERS; MECHANISMS; VECTORS; CELLS; RED; DNA;

D O I：

10.1002/smll.201303329

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A photoprecursor Pc 227 is covalently bound onto gold nanoparticles (Au NPs) to produce the known photodynamic therapy (PDT) drug Pc 4 upon 660 nm photoirradiation. The photochemical formation of the photoproduct Pc 4 is identified by spectroscopy, chromatography, and mass spectrometry and its PDT efficacy is equal to Pc 4 when administered non-covalently by Au NPs, with the added benefit of improved covalent delivery and targeted NIR-triggered release from the covalent Pc 227-Au NP conjugate, while during transport the attached Pc 227 is quenched by the Au NP and PDT inactivated.

引用

页码：1799 / 1804

页数：6

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