The effector repertoire of enteropathogenic E-coli: ganging up on the host cell

被引：165

作者：

Dean, Paul ^{[1
]}

Kenny, Brendan ^{[1
]}

机构：

[1] Univ Newcastle, Inst Cell & Mol Biosci, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

CURRENT OPINION IN MICROBIOLOGY | 2009年 / 12卷 / 01期

基金：

英国惠康基金;

关键词：

III SECRETION SYSTEM; CITROBACTER-RODENTIUM INFECTION; HUMAN INTESTINAL-MUCOSA; DISRUPTION IN-VIVO; ACTIN POLYMERIZATION; EFFACING PATHOGENS; SIGNALING PATHWAYS; SHIGELLA-FLEXNERI; VIRULENCE FACTOR; ESPF INTERACTS;

D O I：

10.1016/j.mib.2008.11.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Diarrhoeal disease caused by enteropathogenic E. coli (EPEC) is dependent on a delivery system that injects numerous bacterial 'effector' proteins directly into host cells. The best-described EPEC effectors are encoded together on the locus of enterocyte effacement (LEE) pathogenicity island and display high levels of multifunctionality and cooperativity within the host cell. More recently, effectors encoded outside the LEE (non-LEE effectors) have been discovered and their functions are beginning to be uncovered. The recent completion of the EPEC genome sequence suggests its effector repertoire consists of at least 21 effector proteins. Here, we describe the genomic location of effectors and discuss recent advances made on effector cellular function as well as their role in the infection process.

引用

收藏

页码：101 / 109

页数：9

相关论文

共 53 条

[1] The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways [J].

Alto, Neal M. ;

Weflen, Andrew W. ;

Rardin, Matthew J. ;

Yarar, Defne ;

Lazar, Cheri S. ;

Tonikian, Raffi ;

Koller, Antonius ;

Taylor, Susan S. ;

Boone, Charles ;

Sidhu, Sachdev S. ;

Schmid, Sandra L. ;

Hecht, Gail A. ;

Dixon, Jack E. .

JOURNAL OF CELL BIOLOGY, 2007, 178 (07) :1265-1278

[2] Identification of a bacterial type III effector family with G protein mimicry functions [J].

Alto, NM ;

Shao, F ;

Lazar, CS ;

Brost, RL ;

Chua, G ;

Mattoo, S ;

McMahon, SA ;

Ghosh, P ;

Hughes, TR ;

Boone, C ;

Dixon, JE .

CELL, 2006, 124 (01) :133-145

[3] Enteropathogenic Escherichia coli Tir is an SH2/3 ligand that recruits and activates tyrosine kinases required for pedestal formation [J].

Bommarius, Bettina ;

Maxwell, David ;

Swimm, Alyson ;

Leung, Sara ;

Corbett, Anita ;

Bornmann, William ;

Kalman, Daniel .

MOLECULAR MICROBIOLOGY, 2007, 63 (06) :1748-1768

[4] Enteropathogenic Escherichia coli:: unravelling pathogenesis [J].

Chen, HD ;

Frankel, G .

FEMS MICROBIOLOGY REVIEWS, 2005, 29 (01) :83-98

[5] Structural mechanism of WASP activation by the enterohaemorrhagic E-coli effector EspFU [J].

Cheng, Hui-Chun ;

Skehan, Brian M. ;

Campellone, Kenneth G. ;

Leong, John M. ;

Rosen, Michael K. .

NATURE, 2008, 454 (7207) :1009-U54

[6] EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics [J].

Dahan, S ;

Wiles, S ;

La Ragione, RM ;

Best, A ;

Woodward, MJ ;

Stevens, MP ;

Shaw, RK ;

Chong, YW ;

Knutton, S ;

Phillips, A ;

Frankel, G .

INFECTION AND IMMUNITY, 2005, 73 (02) :679-686

[7] EPEC's weapons of mass subversion [J].

Dean, P ;

Maresca, M ;

Kenny, B .

CURRENT OPINION IN MICROBIOLOGY, 2005, 8 (01) :28-34

[8] Intestinal barrier dysfunction by enteropathogenic Escherichia coli is mediated by two effector molecules and a bacterial surface protein [J].

Dean, P ;

Kenny, B .

MOLECULAR MICROBIOLOGY, 2004, 54 (03) :665-675

[9] Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins [J].

Dean, P ;

Maresca, M ;

Schüller, S ;

Phillips, AD ;

Kenny, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (06) :1876-1881

[10] Dissecting virulence:: Systematic and functional analyses of a pathogenicity island [J].

Deng, WY ;

Puente, JL ;

Gruenheid, S ;

Li, Y ;

Vallance, BA ;

Vázquez, A ;

Barba, J ;

Ibarra, JA ;

O'Donnell, P ;

Metalnikov, P ;

Ashman, K ;

Lee, S ;

Goode, D ;

Pawson, T ;

Finlay, BB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (10) :3597-3602

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