Opinion - Actin up in the nucleus

被引：199

作者：

Bettinger, BT ^{[1
]}

Gilbert, DM ^{[1
]}

Amberg, DC ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Dept Biochem & Mol Biol, Syracuse, NY 13210 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 05期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1038/nrm1370

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Scepticism regarding the existence of actin in the nucleus is finally giving way to the productive investigation of its functional roles. The identification of actin in several nuclear complexes implicates it in diverse nuclear activities including transcription, chromatin remodelling and nucleocytoplasmic trafficking. A major challenge is that actin does not seem to form large filamentous structures in the nucleus and might adopt unique conformations, the elucidation of which would greatly assist our understanding of its functions.

引用

页码：410 / 415

页数：7

共 61 条

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