Melatonin present in beer contributes to increase the levels of melatonin and antioxidant capacity of the human serum

被引:124
作者
Maldonado, Maria D. [1 ]
Moreno, Hector [1 ]
Calvo, Juan R. [1 ]
机构
[1] Univ Seville, Sch Med, Dept Med Biochem & Mol Biol, E-41009 Seville, Spain
关键词
Beer; Melatonin; Oxidative stress; Human serum; Diet; QUALITY; INJURY;
D O I
10.1016/j.clnu.2009.02.001
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background & aim: Melatonin is a molecule with antioxidative properties including direct free radical scavenging and indirect stimulatory actions on a variety of antioxidative enzymes which further promote its ability to reduce the toxicity of radicals and their associated reactants. Beer is an integral element of the diet of numerous people and is rich in antioxidants. We analyzed if melatonin is present in beer and if so, at what concentration. It further determines whether the moderate consumption of beer has an effect on the total antioxidant Status (TAS) of human serum. Methods: We analyzed 18 brands of beer with different percentage of alcohol content in order to determine the concentration of melatonin. Serum samples were collected from 7 healthy volunteers. These samples were used to measure melatonin and TAS on basal conditions and after drinking beer. Results: Showed that all the beer analyzed did indeed contain melatonin and the more they have got, the greater was its degree of alcohol. Both melatonin and TAS in human serum increased after drinking beer. Conclusions: Melatonin present in the beer does contribute to the total antioxidative capability of human serum and moderate beer consumption can protect organism from overall oxidative stress. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码:188 / 191
页数:4
相关论文
共 36 条
[1]   Gender differences in pharmacokinetics of alcohol [J].
Baraona, E ;
Abittan, CS ;
Dohmen, K ;
Moretti, M ;
Pozzato, G ;
Chayes, ZW ;
Schaefer, C ;
Lieber, CS .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2001, 25 (04) :502-507
[2]   Physiological levels of melatonin contribute to the antioxidant capacity of human serum [J].
Benot, S ;
Goberna, R ;
Reiter, RJ ;
Garcia-Mauriño, S ;
Osuna, C ;
Guerrero, JM .
JOURNAL OF PINEAL RESEARCH, 1999, 27 (01) :59-64
[3]   Effect of non-alcoholic compounds of alcoholic drinks on the pancreas [J].
Feick, Peter ;
Gerloff, Andreas ;
Singer, Manfred V. .
PANCREATOLOGY, 2007, 7 (2-3) :124-130
[4]   Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture [J].
Garcia-Navarro, Ana ;
Gonzalez-Puga, Cristina ;
Escames, Germaine ;
Lopez, Luis C. ;
Lopez, Ana ;
Lopez-Cantarero, Manuel ;
Camacho, Encarnacion ;
Espinosa, Antonio ;
Gallo, Miguel Angel ;
Acuna-Castroviejo, Dario .
JOURNAL OF PINEAL RESEARCH, 2007, 43 (02) :195-205
[5]   Beer consumption reduces cerebral oxidation caused by aluminum toxicity by normalizing gene expression of tumor necrotic factor alpha and several antioxidant enzymes [J].
Gonzalez-Munoz, M. J. ;
Meseguera, I. ;
Sanchez-Reus, M. I. ;
Schultz, A. ;
Olivero, R. ;
Benedi, J. ;
Sanchez-Muniz, F. J. .
FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (03) :1111-1118
[6]   Bioactivity of beer and its influence on human metabolism [J].
Gorinstein, Shela ;
Caspi, Abraham ;
Libman, Imanuel ;
Leontowicz, Hanna ;
Leontowicz, Maria ;
Tashma, Zev ;
Katrich, Elena ;
Jastrzebski, Zenon ;
Trakhtenberg, Simon .
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2007, 58 (02) :94-107
[7]   Correlation of malt quality parameters and beer flavor stability:: Multivariate analysis [J].
Guido, Luis F. ;
Curto, Andreia F. ;
Boivin, Patrick ;
Benismail, Nizar ;
Goncalves, Cristina R. ;
Barros, Aquiles A. .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (03) :728-733
[8]   Increased bioavailability of oral melatonin after fluvoxamine coadministration [J].
Härtter, S ;
Grözinger, M ;
Weigmann, H ;
Röschke, J ;
Hiemke, C .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 67 (01) :1-6
[9]   Protective effect of melatonin against hippocampal injury of rats with intermittent hypoxia [J].
Hung, Ming-Wai ;
Tipoe, George L. ;
Poon, Angela Ming-See ;
Reiter, Russel J. ;
Fung, Man-Lung .
JOURNAL OF PINEAL RESEARCH, 2008, 44 (02) :214-221
[10]   Grape phytochemicals:: A bouquet of old and new nutraceuticals for human health [J].
Iriti, Marcello ;
Faoro, Franco .
MEDICAL HYPOTHESES, 2006, 67 (04) :833-838