Fourier deconvolution reveals the role of the Lorentz function as the convolution kernel of narrow photon beams

被引:22
作者
Djouguela, Armand [1 ,2 ]
Harder, Dietrich [3 ]
Kollhoff, Ralf [1 ,2 ]
Foschepoth, Simon [1 ,2 ]
Kunth, Wolfgang [1 ,2 ]
Ruehmann, Antje [1 ,2 ]
Willborn, Kay [2 ]
Poppe, Bjoern [1 ,2 ]
机构
[1] Carl von Ossietzky Univ Oldenburg, Med Radiat Phys Grp, D-2900 Oldenburg, Germany
[2] Pius Hosp, Dept Radiotherapy & Oncol, Oldenburg, Germany
[3] Univ Gottingen, Gottingen, Germany
关键词
SIZE PENCIL BEAM; MONTE-CARLO; FINITE-SIZE; DOSIMETRIC CHARACTERISTICS; PENUMBRAL MEASUREMENTS; OUTPUT FACTORS; MODEL; OPTIMIZATION; ALGORITHM; DIODE;
D O I
10.1088/0031-9155/54/9/015
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
The two-dimensional lateral dose profiles D(x, y) of narrow photon beams, typically used for beamlet-based IMRT, stereotactic radiosurgery and tomotherapy, can be regarded as resulting from the convolution of a two-dimensional rectangular function R(x, y), which represents the photon fluence profile within the field borders, with a rotation-symmetric convolution kernel K(r). This kernel accounts not only for the lateral transport of secondary electrons and small-angle scattered photons in the absorber, but also for the 'geometrical spread' of each pencil beam due to the phase-space distribution of the photon source. The present investigation of the convolution kernel was based on an experimental study of the associated line-spread function K(x). Systematic cross-plane scans of rectangular and quadratic fields of variable side lengths were made by utilizing the linear current versus dose rate relationship and small energy dependence of the unshielded Si diode PTW 60012 as well as its narrow spatial resolution function. By application of the Fourier convolution theorem, it was observed that the values of the Fourier transform of K(x) could be closely fitted by an exponential function exp(-2 pi lambda nu(x)) of the spatial frequency nu(x). Thereby, the line-spread function K(x) was identified as the Lorentz function K(x) = (lambda/p)[1/(x(2) + lambda(2))], a single-parameter, bell-shaped but non-Gaussian function with a narrow core, wide curve tail, full half-width 2 lambda and convenient convolution properties. The variation of the 'kernel width parameter' lambda with the photon energy, field size and thickness of a water-equivalent absorber was systematically studied. The convolution of a rectangular fluence profile with K(x) in the local space results in a simple equation accurately reproducing the measured lateral dose profiles. The underlying 2D convolution kernel (point-spread function) was identified as K(r) = (lambda/2 pi)[1/(r(2) + lambda(2))](3/2), fitting experimental results as well. These results are discussed in terms of their use for narrow-beam treatment planning.
引用
收藏
页码:2807 / 2827
页数:21
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