Protein flexibility and drug design: how to hit a moving target

被引：256

作者：

Carlson, HA ^{[1
]}

机构：

[1] Univ Michigan, Dept Med Chem, Coll Pharm, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(02)00341-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.

引用

页码：447 / 452

页数：6

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