Development of novel chiral urea catalysts for the hetero-Michael reaction

被引：48

作者：

Sohtome, Y ^{[1
]}

Tanatani, A ^{[1
]}

Hashimoto, Y ^{[1
]}

Nagasawa, K ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 04期

关键词：

organoctatalyst; chiral urea catalyst; hetero-Michael reaction;

D O I：

10.1248/cpb.52.477

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chiral urea compounds 10a-g were synthesized as catalysts for conjugate addition of pyrrolidine (2) to gamma-crotonolactone (3). In the presence of a catalytic amount of the chiral ureas, this hetero-Michael reaction was greatly accelerated. Asymmetric induction was observed with the catalysts 10e, 10f, and 10g.

引用

页码：477 / 480

页数：4

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