The in vitro transport of model thiodipeptide prodrugs designed to target the intestinal oligopeptide transporter, PepT1

被引：22

作者：

Foley, David ^{[1
,2
]}

Pieri, Myrtani ^{[3
]}

Pettecrew, Rachel ^{[2
]}

Price, Richard ^{[2
]}

Miles, Stephen ^{[2
]}

Lam, Ho Kam ^{[2
]}

Bailey, Patrick ^{[1
]}

Meredith, David ^{[3
]}

机构：

[1] Keele Univ, Fac Nat Sci, Keele ST5 5BG, Staffs, England

[2] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

[3] Oxford Brookes Univ, Sch Life Sci, Oxford OX3 0BP, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 18期

基金：

英国惠康基金;

关键词：

ANTIINFLAMMATORY ACTIVITY; CONVENIENT REAGENT; GROWTH-INHIBITION; DRUG DISCOVERY; ACID; CACO-2; AFFINITY; HPEPT1; FLOXURIDINE; ABSORPTION;

D O I：

10.1039/b909221h

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A thiodipeptide carrier system is shown to be effective at enabling a range of covalently bound molecules, including benzyl, benzoyl and ibuprofen conjugates, to be transported via the intestinal peptide transporter PepT1, demonstrating its potential as a rational drug delivery target.

引用

页码：3652 / 3656

页数：5

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