Fitness cost of drug resistance in Mycobacterium tuberculosis

被引：83

作者：

Gagneux, S. ^{[1
]}

机构：

[1] Natl Inst Med Res, MRC, Div Mycobacterial Res, London NW7 1AA, England

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2009年 / 15卷

基金：

英国医学研究理事会;

关键词：

Antibiotic; competition; genotype; mutation; mycobacteria; transmission; ANTIBIOTIC-RESISTANCE; MUTATIONS; EVOLUTION; HUMANS; KATG;

D O I：

10.1111/j.1469-0691.2008.02685.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Multidrug-resistant (MDR) - and extensively drug-resistant (XDR) - forms of tuberculosis are growing public health problems. Mathematical models predict that the future of the MDR and XDR tuberculosis epidemics depends in part on the competitive fitness of drug-resistant strains. Here, recent experimental and molecular epidemiological data that illustrate how heterogeneity among drug-resistant strains of Mycobacterium tuberculosis can influence the relative fitness and transmission of this pathogen are reviewed.

引用

页码：66 / 68

页数：3

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