AMPK at the Nexus of Energetics and Aging

被引：453

作者：

Burkewitz, Kristopher ^{[1
]}

Zhang, Yue ^{[1
]}

Mair, William B. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

来源：

CELL METABOLISM | 2014年 / 20卷 / 01期

关键词：

ACTIVATED PROTEIN-KINASE; LIFE-SPAN EXTENSION; CREB COACTIVATOR TORC2; DIETARY RESTRICTION; C; ELEGANS; CAENORHABDITIS-ELEGANS; SKELETAL-MUSCLE; CALORIC RESTRICTION; DROSOPHILA-MELANOGASTER; CELLULAR-ENERGY;

D O I：

10.1016/j.cmet.2014.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

When energy supply is low, organisms respond by slowing aging and increasing resistance to diverse age-related pathologies. Targeting the mechanisms underpinning this response may therefore treat multiple disorders through a single intervention. Here, we discuss AMP-activated protein kinase (AMPK) as an integrator and mediator of several pathways and processes linking energetics to longevity. Activated by low energy, AMPK is both prolongevity and druggable, but its role in some pathologies may not be beneficial. As such, activating AMPK may modulate multiple longevity pathways to promote healthy aging, but unlocking its full potential may require selective targeting toward substrates involved in longevity assurance.

引用

页码：10 / 25

页数：16

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