Copper-catalyzed cyclization reactions for the synthesis of alkaloids

被引：72

作者：

Evano, Gwilherm ^{[1
]}

Toumi, Mathieu ^{[2
]}

Coste, Alexis ^{[1
]}

机构：

[1] Univ Versailles St Quentin Yvelines, Inst Lavoisier Versailles, CNRS, UMR 8180, F-78035 Versailles, France

[2] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 28期

关键词：

MEDIATED COUPLING REACTIONS; CONCISE TOTAL-SYNTHESIS; N BOND FORMATION; C-H; CYCLOPEPTIDE ALKALOIDS; ARYL BROMIDES; STRAIGHTFORWARD SYNTHESIS; TRYPTAMINE DERIVATIVES; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT;

D O I：

10.1039/b905601g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper-mediated Ullmann type transformations have recently evolved as useful and valuable synthetic tools in organic synthesis. If newly developed catalytic systems are readily available, inexpensive, and tolerate most functional groups, they also provide new opportunities in natural product synthesis since they allow new and efficient retrosynthetic disconnections. They are also especially convenient for the development of straightforward cyclization and macrocyclization procedures. The present article showcases some examples of copper-catalyzed cyclization reactions for the synthesis of alkaloids we have recently developed.

引用

页码：4166 / 4175

页数：10

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