The Faustian bargain of genetic association studies: Bigger might not be better, or at least it might not be good enough

被引:21
作者
Vercelli, Donata [1 ]
Martinez, Fernando D. [1 ]
机构
[1] Univ Arizona, Coll Med, Resp Ctr, Tucson, AZ 85721 USA
关键词
genetics;
D O I
10.1016/j.jaci.2006.03.030
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:1303 / 1305
页数:3
相关论文
共 34 条
[1]   Framework for a fully powered risk engine [J].
不详 .
NATURE GENETICS, 2005, 37 (11) :1153-1153
[2]   Phenotype definition, age, and gender in the genetics of asthma and atopy [J].
Bottema, RW ;
Reijmerink, NE ;
Koppelman, GH ;
Kerkhof, M ;
Postma, DS .
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA, 2005, 25 (04) :621-+
[3]   Environmental exposure to endotoxin and its relation to asthma in school-age children [J].
Braun-Fahrländer, C ;
Riedler, J ;
Herz, U ;
Eder, W ;
Waser, M ;
Grize, L ;
Maisch, S ;
Carr, D ;
Gerlach, F ;
Bufe, A ;
Lauener, RP ;
Schierl, R ;
Renz, H ;
Nowak, D ;
von Mutius, E .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :869-877
[4]   A meta-analysis of the association between childhood type 1 diabetes and atopic disease [J].
Cardwell, CR ;
Shields, MD ;
Carson, DJ ;
Patterson, CC .
DIABETES CARE, 2003, 26 (09) :2568-2574
[5]   Role of regulatory T cells in human diseases [J].
Chatila, TA .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (05) :949-959
[6]   Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments [J].
Eder, W ;
Klimecki, W ;
Yu, LZ ;
von Mutius, E ;
Riedler, J ;
Braun-Fahrländer, C ;
Nowak, D ;
Martinez, FD .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2005, 116 (03) :601-607
[7]  
Hall IP, 2005, THORAX, V60, P357, DOI 10.1136/thx.2005.040790
[8]   An IL-13 promoter polymorphism associated with increased risk of allergic asthma [J].
Kraan, TCTMV ;
van Veen, A ;
Boeije, LCM ;
van Tuyl, SAP ;
de Groot, ER ;
Stapel, SO ;
Bakker, A ;
Verweij, CL ;
Aarden, LA ;
van der Zee, JS .
GENES AND IMMUNITY, 1999, 1 (01) :61-65
[9]   A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity [J].
LeVan, TD ;
Bloom, JW ;
Bailey, TJ ;
Karp, CL ;
Halonen, M ;
Martinez, FD ;
Vercelli, D .
JOURNAL OF IMMUNOLOGY, 2001, 167 (10) :5838-5844
[10]   Genetic polymorphisms in arginase I and II and childhood asthma and atopy [J].
Li, HL ;
Romieu, I ;
Sienra-Monge, JJ ;
Ramirez-Aguilar, M ;
del Rio-Navarro, BE ;
Kistner, EO ;
Gjessing, HK ;
Lara-Sanchez, ID ;
Chiu, GY ;
London, SJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (01) :119-126