Proline-catalyzed ketone-aldehyde aldol reactions are accelerated by water

被引：202

作者：

Nyberg, AI ^{[1
]}

Usano, A ^{[1
]}

Pihko, PM ^{[1
]}

机构：

[1] Aalto Univ, Organ Chem Lab, FI-02015 Helsinki, Finland

来源：

SYNLETT | 2004年 / 11期

关键词：

aldehydes; aldol reactions; ketones; proline catalysis; water;

D O I：

10.1055/s-2004-831296

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Proline-catalyzed aldol reactions between acetone or 4-thianone and different aldehydes are accelerated by addition of 110 equivalents of water to the reaction medium, allowing stoichiometric aldol reactions to proceed at acceptable rates.

引用

页码：1891 / 1896

页数：6

共 30 条

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