The efficient asymmetric synthesis of the antifungal pyrrolidine alkaloid (+)-preussin (2) was accomplished via the stereoselective reduction of a 5-substituted 3-oxo proline. The oxo proline was prepared from an N-sulfinyl delta-amino beta-ketoester, a sulfinimine derived polyfunctionalized chiral building block. (C) 2004 Elsevier Ltd. All rights reserved.
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页码:5111 / 5115
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[1]
Bach T, 1998, ANGEW CHEM INT EDIT, V37, P3400, DOI 10.1002/(SICI)1521-3773(19981231)37:24<3400::AID-ANIE3400>3.0.CO