Asymmetric synthesis of (+)-preussin from N-sulfinyl δ-amino β-ketoesters

被引:35
作者
Davis, FA [1 ]
Deng, JH [1 ]
机构
[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA
关键词
D O I
10.1016/j.tet.2004.03.094
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The efficient asymmetric synthesis of the antifungal pyrrolidine alkaloid (+)-preussin (2) was accomplished via the stereoselective reduction of a 5-substituted 3-oxo proline. The oxo proline was prepared from an N-sulfinyl delta-amino beta-ketoester, a sulfinimine derived polyfunctionalized chiral building block. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5111 / 5115
页数:5
相关论文
共 21 条