pH dependence of the rate of DNA alkylation for (+)-duocarmycin SA and (+)-CCBI-TMI

被引：28

作者：

Boger, DL

Boyce, CW

Johnson, DS

机构：

[1] Department of Chemistry, Scripps Research Institute, San Diego, CA 92037

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(96)00605-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A study of the DNA alkylation rate pH dependence with the establishment of pseudo first-order rate constants for 1 and 3 at a single high affinity site in w794 DNA is detailed. This dependence proved to be remarkably small with the rates increasing only 1.89x and 2.5x, respectively, over 2 pH units (pH 6-8). (C) 1997, Elsevier Science Ltd.

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页码：233 / 238

页数：6

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