The hematopoietic stem cell niche in homeostasis and disease

被引：206

作者：

Calvi, Laura M. ^{[1
]}

Link, Daniel C. ^{[2
,3
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Med & Pharmacol & Physiol, Rochester, NY 14642 USA

[2] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

来源：

BLOOD | 2015年 / 126卷 / 22期

基金：

美国国家卫生研究院;

关键词：

BONE-MARROW NICHE; MESENCHYMAL STROMAL CELLS; SELF-RENEWAL; PARATHYROID-HORMONE; PROGENITOR CELLS; VASCULAR NICHE; G-CSF; STEM/PROGENITOR CELLS; OSTEOBLASTIC CELLS; ENDOTHELIAL NICHES;

D O I：

10.1182/blood-2015-07-533588

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that they generate. We highlight emerging data that stem cell niches in the bone marrow are not static but instead are responsive to environmental stimuli. Finally, we review recent data showing that hematopoietic niches are altered in certain hematopoietic malignancies, and we discuss how these alterations might contribute to disease pathogenesis.

引用

页码：2443 / 2451

页数：9

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