Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells

被引：51

作者：

Sharifi, Simin ^{[1
]}

Moghaddam, Farzin Arablouye ^{[2
]}

Abedi, Atefeh ^{[2
]}

Maleki Dizaj, Solmaz ^{[1
]}

Ahmadian, Shahin ^{[3
,4
]}

Abdolahinia, Elaheh Dalir ^{[5
]}

Khatibi, Seyed Mahdi Hosseiniyan ^{[6
]}

Samiei, Mohammad ^{[2
,3
]}

机构：

[1] Tabriz Univ Med Sci, Dent & Periodontal Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Dent, Dept Endodont, Tabriz, Iran

[3] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran

[4] Azarbaijan Shahid Madani Univ, Fac Basic Sci, Dept Biol, Tabriz, Iran

[5] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[6] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran

来源：

BIOFACTORS | 2020年 / 46卷 / 06期

关键词：

mesenchymal stem cells; osteoblast; osteogenic differentiation; phytochemicals; HUMAN ADIPOSE-TISSUE; STEROID-ASSOCIATED OSTEONECROSIS; HUMAN BONE-MARROW; HUMAN PERIODONTAL-LIGAMENT; GREEN TEA CONSUMPTION; PROOF-OF-CONCEPT; IN-VITRO; OSTEOBLAST DIFFERENTIATION; PHYTOMOLECULE ICARITIN; STROMAL CELLS;

D O I：

10.1002/biof.1682

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Medicinal plants have always been utilized for the prevention and treatment of the spread of different diseases all around the world. To name some traditional medicine that has been used over centuries, we can refer to phytochemicals such as naringin, icariin, genistein, and resveratrol gained from plants. Osteogenic differentiation and mineralization of stem cells can be the result of specific bioactive compounds from plants. One of the most appealing choices for therapy can be mesenchymal stem cells (MSCs) because it has a great capability of self-renewal and differentiation into three descendants, namely, endoderm, mesoderm, and ectoderm. Stem cell gives us the glad tidings of great advances in tissue regeneration and transplantation field for treatment of diseases. Using plant bioactive phytochemicals also holds tremendous promises in treating diseases such as osteoporosis. The purpose of the present review article thus is to investigate what are the roles and consequences of phytochemicals on osteogenic differentiation of MSCs.

引用

页码：874 / 893

页数：20

共 176 条

[71]

Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP pathway [J].