High-throughput gene expression analysis for drug discovery

被引：34

作者：

Lennon, GG ^{[1
]}

机构：

[1] Gene Log, Gaithersburg, MD 20878 USA

来源：

DRUG DISCOVERY TODAY | 2000年 / 5卷 / 02期

关键词：

D O I：

10.1016/S1359-6446(99)01448-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The ability to rapidly survey and compare gene expression levels between reference and test samples is moving the drug discovery process towards a more genomic orientation. The success of the Human Genome Project and related private genomics initiatives, combined with new technologies to probe, image and access expression data, are responsible for this transformation. This article reviews the history, status and future direction of high-throughput gene expression analysis. It describes classical approaches, explains the development of methods such as differential display for discovering novel genes, and discusses how microarray technology is exploiting collections of known sequences to pinpoint drug targets.

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页码：59 / 66

页数：8

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