Large-scale oxidations in the pharmaceutical industry

被引：732

作者：

Caron, Stephane ^{[1
]}

Dugger, Robert W. ^{[1
]}

Ruggeri, Sally Gut ^{[1
]}

Ragan, John A. ^{[1
]}

Ripin, David H. Brown ^{[1
]}

机构：

[1] Pfizer Inc, Chem Res & Dev, Pfizer Global Res Div, Groton, CT 06340 USA

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 07期

关键词：

D O I：

10.1021/cr040679f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidation reactions are powerful tools to convert a position that is protected in a lower oxidation state to the desired functionality and for the functionalization of otherwise unfunctionalized positions. Despite their power as a synthetic tool, these reactions are not fully utilized in the pharmaceutical industry. To illustrate the reasons for this hesitation, an overview is given of the currently acceptable methods for large-scale oxidations of alkenes, arenes, alkylarenes, alcohols, amines, sulfides, and other substrates. It is shown that the Moffat oxidation and TEMPO-based oxidants are especially valuable for the conversion of primary alcohols into aldehydes.

引用

页码：2943 / 2989

页数：47

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