In search of peptide-based catalysts for asymmetric organic synthesis

被引：364

作者：

Miller, SJ ^{[1
]}

机构：

[1] Boston Coll, Chestnut Hill, MA 02467 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2004年 / 37卷 / 08期

关键词：

D O I：

10.1021/ar030061c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The discovery of short peptide sequences that function as asymmetric catalysts for a variety of reactions is documented. The evolution of the project from an exercise in rational design to an endeavor that combines combinatorial screening with various mechanism-based experiments is presented. The specific development of catalysts for enantioselective acylation, phosphorylation, conjugate addition, and Morita-Baylis-Hillman reactions is described.

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页码：601 / 610

页数：10

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