Solid phase sequential 1,3-dipolar cycloaddition-Pictet-Spengler reactions

被引：54

作者：

Dondas, HA

Grigg, R ^{[1
]}

MacLachlan, WS

MacPherson, DT

Markandu, J

Sridharan, V

Suganthan, S

机构：

[1] Univ Leeds, Sch Chem, Mol Innovat Divers & Automated Synth Ctr, Leeds LS2 9JT, W Yorkshire, England

[2] SmithKline Beecham, Harlow CM19 5AW, Essex, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 06期

基金：

英国工程与自然科学研究理事会;

关键词：

cycloaddition; Pictet-Spengler reaction; Pd catalysis; cascade reaction;

D O I：

10.1016/S0040-4039(99)02183-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Up to six bonds and two rings can be created, in five component processes (five points of diversity), by AgOAc catalysed imine cycloaddition to Wang resin acrylate followed by Pictet-Splengler and Pd(0) catalysed reactions. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：967 / 970

页数：4

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