Virus-specific CD8+ T lymphocytes within the normal human

被引：29

作者：

Ward, SM

Jonsson, JR

Sierro, S

Clouston, AD

Lucas, M

Vargas, AL

Powell, EE

Klenerman, P

机构：

[1] Univ Oxford, Nuffield Dept Clin Med, Oxford, England

[2] Univ Queensland, Princess Alexandra Hosp, Dept Surg, Brisbane, Qld, Australia

[3] Univ Queensland, Princess Alexandra Hosp, Dept Pathol, Brisbane, Qld, Australia

[4] Univ Queensland, Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2004年 / 34卷 / 06期

关键词：

human liver; tetramer; phenotype; CTL;

D O I：

10.1002/eji.200324275

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The frequency and phenotype of human antiviral memory CD8(+) T cells in blood are well studied, yet little is known about their distribution within tissues. Analysis of antiviral CD8(+) T cell populations derived from a unique set of normal liver and blood samples identified a consistent population of virus-specific cells within the liver. In comparison to the circulating T cells, the liver-derived T cells were present at frequencies which were variably enriched compared to that in the blood, and showed significant differences with regard to the expression of CD45RA, CD45RO, CD95, CCR7, CD27 and CD28. The differences in these cell surface markers are consistent with a mature 'effector memory' phenotype of antigen-specific CD8(+) T cells within the liver. An enrichment of an activated subset of NKT cells (Valpha24/Vbeta11) was also observed, a finding which may be relevant to the regulation of the antiviral population:.

引用

页码：1526 / 1531

页数：6

共 32 条

[21] Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection [J].