Frequency and phenotype of circulating Vα24/Vβ11 double-positive natural killer T cells during hepatitis C virus infection

被引：89

作者：

Lucas, M

Gadola, S

Meier, U

Young, NT

Harcourt, G

Karadimitris, A

Coumi, N

Brown, D

Dusheiko, G

Cerundolo, V

Klenerman, P

机构：

[1] Univ Oxford, Nuffield Dept Med, Weatherall Inst Mol Med, Oxford OX1 3SY, England

[2] John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

[3] Royal Free Hosp, Ctr Hepatol, London NW3 2QG, England

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 03期

关键词：

D O I：

10.1128/JVI.77.3.2251-2257.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Natural killer T (NKT) cells are thought to be involved in innate responses against infection. We investigated one specific type of NKT cell, Valpha24/Vbeta11 double positive, in hepatitis C virus (HCV) infection. Lower frequencies of this population were detected in the blood of HCV PCR-positive patients than in controls. Unlike Valpha24/Vbeta11 NKT cells found in blood, those in the liver appeared to be recently activated.

引用

页码：2251 / 2257

页数：7

共 34 条

[1] Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection [J].