The intestinal LABs

被引:122
作者
Vaughan, EE
de Vries, MC
Zoetendal, EG
Ben-Amor, K
Akkermans, ADL
de Vos, WM
机构
[1] Univ Wageningen, Microbiol Lab, NL-6703 CT Wageningen, Netherlands
[2] Wageningen Ctr Food Sci, NL-6700 AN Wageningen, Netherlands
来源
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY | 2002年 / 82卷 / 1-4期
关键词
bifidobacteria; intestine; lactic acid bacteria; microbiota; molecular methods; 16S rRNA;
D O I
10.1023/A:1020672724450
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The complete gastrointestinal (GI) tract of humans is colonised soon after birth by a myriad of microbial species with a characteristic distribution depending on the location. GI-tract ecology has been experiencing a revival due to the development of molecular techniques, especially those based on 16S RNA (zRNA) genes. A richer ecosystem than previously imagined of novel species is being discovered that is significantly influenced by our host genotype. Special attention has been focused on the bifidobacteria and the lactic acid bacterial (LAB) populations, both those that are naturally present within this complex ecosystem and those that are ingested as probiotics in functional foods. Overall this interest stems from a increasing awareness of interplay between microflora, diet and the health of the host, and is further stimulated by an increasing incidence of gastrointestinal illnesses and atopy. Substantial documentation of benefits to host health has especially distinguished the LAB for multidisciplinary research aimed to determine the molecular mechanisms involved. Recent advances in molecular technologies, including high-throughput genomics-based approaches, can significantly advance our understanding of the microbe-diet-host interactions and offer valuable information for design and application of health-targeted microbes.
引用
收藏
页码:341 / 352
页数:12
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