Palladium(0)-catalyzed Suzuki-Miyaura cross-coupling reactions of potassium aryl- and heteroaryltrifluoroborates with alkenyl bromides

被引：62

作者：

Molander, Gary A. ^{[1
]}

Fumagalli, Tiziano ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 15期

关键词：

ARYLBORONIC ACIDS; ARYL CHLORIDES; LIGANDLESS PALLADIUM; ALKYL BROMIDES; CATALYSTS; AMINATION;

D O I：

10.1021/jo0608366

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient palladium(0)-catalyzed Suzuki-Miyaura cross-couplings are described. The reactions involving potassium aryl- and heteroaryltrifluoroborates with alkenyl bromides can generally be carried out using <= 2 mol % of palladium catalyst and 3 equiv of base in toluene/H2O. When stereodefined alkenyl bromides are employed, the resulting styrene derivatives are accessed stereospecifically. A variety of functional groups are tolerated in both coupling partners.

引用

页码：5743 / 5747

页数：5

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