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Palladium(0)-catalyzed Suzuki-Miyaura cross-coupling reactions of potassium aryl- and heteroaryltrifluoroborates with alkenyl bromides
被引:62
作者:
Molander, Gary A.
[1
]
Fumagalli, Tiziano
[1
]
机构:
[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA
关键词:
ARYLBORONIC ACIDS;
ARYL CHLORIDES;
LIGANDLESS PALLADIUM;
ALKYL BROMIDES;
CATALYSTS;
AMINATION;
D O I:
10.1021/jo0608366
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Efficient palladium(0)-catalyzed Suzuki-Miyaura cross-couplings are described. The reactions involving potassium aryl- and heteroaryltrifluoroborates with alkenyl bromides can generally be carried out using <= 2 mol % of palladium catalyst and 3 equiv of base in toluene/H2O. When stereodefined alkenyl bromides are employed, the resulting styrene derivatives are accessed stereospecifically. A variety of functional groups are tolerated in both coupling partners.
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页码:5743 / 5747
页数:5
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