Positive selection of T cells induced by viral delivery of neopeptides to the thymus

被引：98

作者：

Nakano, N

Rooke, R

Benoist, C

Mathis, D

机构：

[1] INSERM, CNRS, Universite Louis Pasteur, 67404 Illkirch, C.U. de Strasbourg

来源：

SCIENCE | 1997年 / 275卷 / 5300期

关键词：

D O I：

10.1126/science.275.5300.678

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The relation between an antigenic peptide that can stimulate a mature T cell and the natural peptide that promoted selection of this cell in the thymus is still unknown. An experimental system was devised to address this issue in vivo-mice expressing neopeptides in thymic stromal cells after adenovirus-mediated delivery of invariant chain-peptide fusion proteins. In this system, selection of T cells capable of responding to a given antigenic peptide could be promoted by the peptide itself, by closely related analogs lacking agonist and antagonist activity, or by ostensibly unrelated peptides. However, the precise repertoire of T cells selected was dictated by the particular neopeptide expressed.

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页码：678 / 683

页数：6

相关论文

共 40 条

[1] PEPTIDE CONTRIBUTES TO THE SPECIFICITY OF POSITIVE SELECTION OF CD8+ T-CELLS IN THE THYMUS [J].

ASHTONRICKARDT, PG ;

VANKAER, L ;

SCHUMACHER, TNM ;

PLOEGH, HL ;

TONEGAWA, S .

CELL, 1993, 73 (05) :1041-1049

[2] EVIDENCE FOR A DIFFERENTIAL AVIDITY MODEL OF T-CELL SELECTION IN THE THYMUS [J].

ASHTONRICKARDT, PG ;

BANDEIRA, A ;

DELANEY, JR ;

VANKAER, L ;

PIRCHER, HP ;

ZINKERNAGEL, RM ;

TONEGAWA, S .

CELL, 1994, 76 (04) :651-663

[3] PHENOTYPIC DIFFERENCES BETWEEN ALPHA-BETA-T-CELL VERSUS BETA-T-CELL RECEPTOR TRANSGENIC MICE UNDERGOING NEGATIVE SELECTION [J].

BERG, LJ ;

FAZEKAS DE ST GROTH, B ;

PULLEN, AM ;

DAVIS, MM .

NATURE, 1989, 340 (6234) :559-562

[4] ISLET-SPECIFIC T-CELL CLONES FROM NONOBESE DIABETIC MICE EXPRESS HETEROGENEOUS T-CELL RECEPTORS [J].

CANDEIAS, S ;

KATZ, J ;

BENOIST, C ;

MATHIS, D ;

HASKINS, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (14) :6167-6170

[5] ANTIGEN-SELECTED T-CELL RECEPTOR DIVERSITY AND SELF-NONSELF HOMOLOGY [J].

CASANOVA, JL ;

MARYANSKI, JL .

IMMUNOLOGY TODAY, 1993, 14 (08) :391-394

[6] MOLECULAR-DETECTION AND INVIVO ANALYSIS OF THE SPECIFIC T-CELL RESPONSE TO A PROTEIN ANTIGEN [J].

COCHET, M ;

PANNETIER, C ;

REGNAULT, A ;

DARCHE, S ;

LECLERC, C ;

KOURILSKY, P .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (10) :2639-2647

[7] SPECIFIC T-CELL RECOGNITION OF MINIMALLY HOMOLOGOUS PEPTIDES - EVIDENCE FOR MULTIPLE ENDOGENOUS LIGANDS [J].

EVAVOLD, BD ;

SLOANLANCASTER, J ;

WILSON, KJ ;

ROTHBARD, JB ;

ALLEN, PM .

IMMUNITY, 1995, 2 (06) :655-663

[8] MOLECULAR ANALYSIS OF THE INFLUENCES OF POSITIVE SELECTION, TOLERANCE INDUCTION, AND ANTIGEN PRESENTATION ON THE T-CELL RECEPTOR REPERTOIRE [J].

FINK, PJ ;

BLAIR, MJ ;

MATIS, LA ;

HEDRICK, SM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :139-150

[9] Antigen presentation and T cell development in H2-M-deficient mice [J].

FungLeung, WP ;

Surh, CD ;

Liljedahl, M ;

Pang, J ;

Leturcq, D ;

Peterson, PA ;

Webb, SR ;

Karlsson, L .

SCIENCE, 1996, 271 (5253) :1278-1281

[10] MHC-DEPENDENT ANTIGEN-PROCESSING AND PEPTIDE PRESENTATION - PROVIDING LIGANDS FOR T-LYMPHOCYTE ACTIVATION [J].

GERMAIN, RN .

CELL, 1994, 76 (02) :287-299

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