A phenol quaternary ammonium porphyrin as a potent telomerase inhibitor by selective interaction with quadruplex DNA

被引：76

作者：

Wang, Ping

Ren, Lige

He, Hanping

Liang, Feng

Zhou, Xiang ^{[1
]}

Tan, Zheng

机构：

[1] Wuhan Univ, Sch Life Sci, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430071, Peoples R China

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 08期

关键词：

G-quadruplexes; inhibitors; phenol; porphyrins; quaternary ammonium; telomerases;

D O I：

10.1002/cbic.200600036

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Not adding anything new? Phenol quaternary ammonium derivatives have been found to cross-link DNA efficiently. Experimental data indicate that a phenol quaternary ammonium cationic porphyrin (TQMP) potently inhibits a telomerase (IC50 = 1.7 μM) due to its selective, stabilizing interactions with G-quadruplexes. These interactions might derive from the greater flexibility of TQMP over pyridinium porphyrins and its steric effect. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：1155 / 1159

页数：5

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