Intramolecular Imino Diels-Alder Reaction: Progress toward the Synthesis of Uncialamycin

被引：47

作者：

Desrat, Sandy ^{[1
]}

van de Weghe, Pierre ^{[1
]}

机构：

[1] Univ Rennes 1, Fac Sci Biol & Pharmaceut, EA Subst Lichen & Photoprotect, F-35043 Rennes, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 17期

关键词：

QUINOLINES; ACID; CYCLIZATION; MARTINELLINE; ALCOHOLS; KETONES; DESIGN;

D O I：

10.1021/jo901291t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein described an intramolecular imino Diels-Alder reaction promoted with BF3.OEt2/DDQ affording substituted quinolines. Using this procedure, we prepared the chiral quitioline moiety of the uncialamycin, a new enediyne natural product.

引用

页码：6728 / 6734

页数：7

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