Integrin signalling: a new Cas(t) of characters enters the stage

被引：252

作者：

O'Neill, GM ^{[1
]}

Fashena, SJ ^{[1
]}

Golemis, EA ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Div Basic Sci, Philadelphia, PA 19111 USA

来源：

TRENDS IN CELL BIOLOGY | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0962-8924(99)01714-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular morphology is determined by the organization of the intracellular actin cytoskeleton, which is influenced by external and internal cues. Focal adhesions are sites at which the actin cytoskeleton is linked to the extracellular matrix by integrin receptor complexes. In addition to providing structural tethering points for cells, integrin receptor complexes transduce signals that influence a broad range of cellular processes, including migration, proliferation, transformation and apoptosis. The Cas proteins (p130Cas, HEF1/Cas-L and Efs/Sin), a family of docking proteins containing multiple interaction domains, are important components of integrin receptor signalling and have been implicated in all of these processes.

引用

页码：111 / 119

页数：9

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