Mechanical properties and biomedical applications of a nanotube hydroxyapatite-reduced graphene oxide composite

被引：291

作者：

Baradaran, S. ^{[1
]}

Moghaddam, E. ^{[2
]}

Basirun, W. J. ^{[3
,8
]}

Mehrali, M. ^{[1
,4
]}

Sookhakian, M. ^{[5
]}

Hamdi, M. ^{[6
]}

Moghaddam, M. R. Nakhaei ^{[7
]}

Alias, Y. ^{[3
]}

机构：

[1] Univ Malaya, Fac Engn, Dept Mech Engn, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Fac Med, Trop Infect Dis Res & Educ Ctr, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[4] Univ Malaya, Fac Engn, Dept Biomed Engn, Kuala Lumpur 50603, Malaysia

[5] Univ Malaya, Fac Sci, Dept Phys, Kuala Lumpur 50603, Malaysia

[6] Univ Malaya, Ctr Adv Mfg & Mat Proc, Kuala Lumpur 50603, Malaysia

[7] Univ Malaya, Fac Med, Dept Orthoped Surg, Kuala Lumpur 50603, Malaysia

[8] Univ Malaya, Inst Nanotechnol & Catalysis Res NanoCat, Kuala Lumpur 50603, Malaysia

来源：

CARBON | 2014年 / 69卷

关键词：

BIOCOMPATIBILITY; NANOCOMPOSITES; FABRICATION; DEPOSITION; MONOLAYER; CARBIDE; RAMAN;

D O I：

10.1016/j.carbon.2013.11.054

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

As a result of the growing interest in the biological and mechanical performance of hydroxyapatite (HA)-graphene nano-sheets (GNs) composite systems, reduced graphene oxide (rGO) reinforced hydroxyapatite nano-tube (nHA) composites were synthesized in situ using a simple hydrothermal method in a mixed solvent system of ethylene glycol (EG), N,N-dimethylformamide (DMF) and water, without using any of the typical reducing agents. The consolidation process was performed by hot isostatic pressing (HIP) at 1150 C and 160 MPa. The composites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy, enabling confirmation of the synthesis and reduction of the nHA and rGO, respectively. The structure of the synthesized powder and cell attachment on the sintered sample was confirmed by field emission scanning electron microscopy (FESEM). The effects of the rGO on the mechanical properties and the in vitro biocompatibility of the nHA based ceramic composites were investigated. The elastic modulus and fracture toughness of the sintered samples increased with the increase of the rGO content when compared to the pure nHA by 86% and 40%, respectively. Cell culture and viability test results showed that the addition of the rGO promotes osteoblast adhesion and proliferation, thereby increasing the biocompatibility of the nHA-rGO composite. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：32 / 45

页数：14

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