All-in-One Target-Cell-Specific Magnetic Nanoparticles for Simultaneous Molecular Imaging and siRNA Delivery

被引：280

作者：

Lee, Jae-Hyun ^{[2
]}

Lee, Kyuri ^{[1
]}

Moon, Seung Ho ^{[2
]}

Lee, Yuhan ^{[1
]}

Park, Tae Gwan ^{[1
]}

Cheon, Jinwoo ^{[2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[2] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 23期

关键词：

drug delivery; magnetic nanoparticles; magnetic resonance imaging; multimodal imaging; siRNA; DRUG-DELIVERY; GENE DELIVERY; VIVO DELIVERY; QUANTUM DOTS; VEGF SIRNA; MICELLES; THERAPY; CANCER; RESONANCE; ENDOSOME;

D O I：

10.1002/anie.200805998

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGDpeptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4174 / 4179

页数：6

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