InterPro in 2017-beyond protein family and domain annotations

被引：1095

作者：

Finn, Robert D. ^{[1
]}

Attwood, Teresa K. ^{[2
]}

Babbitt, Patricia C. ^{[3
]}

Bateman, Alex ^{[1
]}

Bork, Peer ^{[4
]}

Bridge, Alan J. ^{[5
]}

Chang, Hsin-Yu ^{[1
]}

Dosztanyi, Zsuzsanna ^{[6
]}

El-Gebali, Sara ^{[1
]}

Fraser, Matthew ^{[1
]}

Gough, Julian ^{[7
]}

Haft, David ^{[8
]}

Holliday, Gemma L. ^{[3
]}

Huang, Hongzhan ^{[9
]}

Huang, Xiaosong ^{[10
]}

Letunic, Ivica ^{[11
]}

Lopez, Rodrigo ^{[1
]}

Lu, Shennan ^{[12
]}

Marchler-Bauer, Aron ^{[12
]}

Mi, Huaiyu ^{[10
]}

Mistry, Jaina ^{[1
]}

Natale, Darren A. ^{[13
]}

Necci, Marco ^{[14
,15
]}

Nuka, Gift ^{[1
]}

Orengo, Christine A. ^{[16
]}

Park, Youngmi ^{[1
]}

Pesseat, Sebastien ^{[1
]}

Piovesan, Damiano ^{[14
,15
]}

Potter, Simon C. ^{[1
]}

Rawlings, Neil D. ^{[1
]}

Redaschi, Nicole ^{[5
]}

Richardson, Lorna ^{[1
]}

Rivoire, Catherine ^{[5
]}

Sangrador-Vegas, Amaia ^{[1
]}

Sigrist, Christian ^{[5
]}

Sillitoe, Ian ^{[16
]}

Smithers, Ben ^{[7
]}

Squizzato, Silvano ^{[1
]}

Sutton, Granger ^{[8
]}

Thanki, Narmada ^{[12
]}

Thomas, Paul D. ^{[10
]}

Tosatto, Silvio C. E. ^{[14
,15
,17
]}

Wu, Cathy H. ^{[9
]}

Xenarios, Ioannis ^{[5
]}

Yeh, Lai-Su ^{[13
]}

Young, Siew-Yit ^{[1
]}

Mitchell, Alex L. ^{[1
]}

机构：

[1] EBI, EMBL, Wellcome Trust Genome Campus, Cambridge CB10 1SD, England

[2] Univ Manchester, Sch Comp Sci, Manchester, Lancs, England

[3] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

[4] European Mol Biol Lab, Biocomp, Meyerhofstasse 1, D-69117 Heidelberg, Germany

[5] CMU, SIB, Swiss Prot Grp, 1 Rue Michel Servet, CH-1211 Geneva 4, Switzerland

[6] Eotvos Lorand Univ, Dept Biochem, MTA ELTE Lendulet Bioinformat Res Grp, Pazmany Peter Setany 1-C, Budapest, Hungary

[7] Univ Bristol, Dept Comp Sci, Woodland Rd, Bristol BS8 1UB, Avon, England

[8] J Craig Venter Inst, Bioinformat Dept, 9714 Med Ctr Dr, Rockville, MD 20850 USA

[9] Univ Delaware, Ctr Bioinformat & Computat Biol, Newark, DE 19711 USA

[10] Univ Southern Calif, Dept Prevent Med, Div Bioinformat, Los Angeles, CA 90033 USA

[11] Biobyte Solut GmbH, Bothestr 142, D-69126 Heidelberg, Germany

[12] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH Bldg,38A,8600 Rockville Pike, Bethesda, MD 20894 USA

[13] Georgetown Univ, Med Ctr, 3300 Whitehaven St NW, Washington, DC 20007 USA

[14] Univ Padua, Dept Biomed Sci, Via U Bassi 58-B, I-35131 Padua, Italy

[15] Univ Padua, CRIBI Biotech Ctr, Via U Bassi 58-B, I-35131 Padua, Italy

[16] UCL, Struct & Mol Biol, Darwin Bldg, London WC1E 6BT, England

[17] CNR, Inst Neurosci, Via U Bassi 58-B, I-35131 Padua, Italy

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

基金：

美国国家卫生研究院; 英国惠康基金; 英国生物技术与生命科学研究理事会; 美国国家科学基金会;

关键词：

METABOLIC PATHWAYS; DATABASE; RESOURCE; GENOME; CLASSIFICATION; DISORDER; GENE; PREDICTION; SEQUENCES; SYSTEM;

D O I：

10.1093/nar/gkw1107

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

InterPro (http://www.ebi.ac.uk/interpro/) is a freely available database used to classify protein sequences into families and to predict the presence of important domains and sites. InterProScan is the underlying software that allows both protein and nucleic acid sequences to be searched against InterPro's predictive models, which are provided by its member databases. Here, we report recent developments with InterPro and its associated software, in-cluding the addition of two new databases (SFLD and CDD), and the functionality to include residue-level annotation and prediction of intrinsic disorder. These developments enrich the annotations provided by InterPro, increase the overall number of residues annotated and allow more specific functional inferences.

引用

页码：D190 / D199

页数：10

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