BMP2 shows neurotrophic effects including neuroprotection against neurodegeneration

被引：6

作者：

Saglam, Aybike ^{[1
]}

Kim, Sukbum ^{[2
]}

Ahn, Kwangwook ^{[1
]}

Oh, Insuk ^{[3
]}

Lee, Kwan-Hee ^{[1
]}

机构：

[1] TissueGene Inc, Rockville, MD 20850 USA

[2] Gachon Univ, Gil Med Ctr, Dept Orthoped Surg, Inchon, South Korea

[3] Uniformed Force Capital Hosp, Dept Orthoped, Kyunggido, South Korea

来源：

NEUROREPORT | 2014年 / 25卷 / 08期

关键词：

bone morphogenetic protein 2; microtubule; neuroprotection; PI3K; PTEN; SPINAL-CORD; AXON REGENERATION; PROTEIN; CNS; INHIBITION; GROWTH;

D O I：

10.1097/WNR.0000000000000130

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In this study, we found that BMP2 exerts neurotrophic effects, including a neuroprotective effect against nocodazole-induced neuritic degeneration, on neuronal cells. We also found that BMP2-induced neurotrophic effects are directly involved in Smad-dependent signaling as well as PI3K/PTEN-Akt-mTOR signaling. Moreover, BMP2-induced neurotrophic effects occur by stabilization of neuronal microtubules. Thus, these findings suggest that BMP2 can be a potential therapeutic target for nerve injury treatment.

引用

收藏

页码：549 / 555

页数：7

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