Chemical analysis in photo structurable glass chips

被引:28
作者
Becker, H
Arundell, M
Harnisch, A
Hülsenberg, D
机构
[1] Mildendo GMBH, D-07745 Jena, Germany
[2] Univ London Imperial Coll Sci Technol & Med, Zeneca Smithkline Beecham Ctr Analyt Sci, London SW7 2AY, England
[3] Tech Univ Ilmenau, Fachgebiet Glas & Keram Technol, D-98685 Ilmenau, Germany
关键词
photostructurable glass; micro-fluidic; fluorescence; amino-acids;
D O I
10.1016/S0925-4005(02)00162-4
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
We have fabricated a capillary electrophoresis (CE) chip from photostructurable glass. This material allows, unlike conventional amorphous glasses, the fabrication of microstructures, namely micro-channels with an aspect ratio of >1 using the wet etching processes. The high aspect ratio allows, for a given channel cross-section, a longer optical path length resulting in improved detection limits for optical detection methods. This paper describes the fabrication of a single depth photostructurable glass device, with dimensions of 500 mum depth and 200 mum width, which was characterised with the CE separation of amino-acids. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:271 / 279
页数:9
相关论文
共 13 条
  • [1] Indirect fluorescence detection of phenolic compounds by capillary electrophoresis on a glass device
    Arundell, M
    Whalley, PD
    Manz, A
    [J]. FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 2000, 367 (08): : 686 - 691
  • [2] Fabrication technologies for microsystems utilizing photoetchable glass
    Dietrich, TR
    Ehrfeld, W
    Lacher, M
    Kramer, M
    Speit, B
    [J]. MICROELECTRONIC ENGINEERING, 1996, 30 (1-4) : 497 - 504
  • [3] GLASS CHIPS FOR HIGH-SPEED CAPILLARY ELECTROPHORESIS SEPARATIONS WITH SUBMICROMETER PLATE HEIGHTS
    EFFENHAUSER, CS
    MANZ, A
    WIDMER, HM
    [J]. ANALYTICAL CHEMISTRY, 1993, 65 (19) : 2637 - 2642
  • [4] MICROMACHINING OF CAPILLARY ELECTROPHORESIS INJECTORS AND SEPARATORS ON GLASS CHIPS AND EVALUATION OF FLOW AT CAPILLARY INTERSECTIONS
    FAN, ZH
    HARRISON, DJ
    [J]. ANALYTICAL CHEMISTRY, 1994, 66 (01) : 177 - 184
  • [5] 3D-structuring of photosensitive glasses
    Feindt, K
    Harnisch, A
    Zoppig, V
    Hulsenberg, D
    Kallenbach, E
    [J]. MICRO ELECTRO MECHANICAL SYSTEMS - IEEE ELEVENTH ANNUAL INTERNATIONAL WORKSHOP PROCEEDINGS, 1998, : 207 - 210
  • [6] Harnisch A, 2000, GLASS SCI TECHNOL, V73, P67
  • [7] GLASSES AND GLASS-CERAMICS FOR APPLICATION IN MICROMECHANICS
    HULSENBERG, D
    BRUNTSCH, R
    [J]. JOURNAL OF NON-CRYSTALLINE SOLIDS, 1991, 129 (1-3) : 199 - 205
  • [8] HULSENBERG D, 1995, P 17 INT C GLASS SPE, V5, P127
  • [9] Microchip structures for submillisecond electrophoresis
    Jacobson, SC
    Culbertson, CT
    Daler, JE
    Ramsey, JM
    [J]. ANALYTICAL CHEMISTRY, 1998, 70 (16) : 3476 - 3480
  • [10] MANZ A, 1993, ADV CHROMATOGR, V33, P1