Stereoselective synthesis of alpha-hydroxy-beta-amino acids using D-glyceraldehyde as the homochiral source.

被引：45

作者：

Cativiela, C

DiazDeVillegas, MD

Galvez, JA

机构：

[1] Inst. de Cie. de Mat. de Aragon, Depto. de Quim. Orgánica, Universidad de Zaragoza-C.S.I.C.

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 02期

关键词：

D O I：

10.1016/0957-4166(96)00037-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A systematic study of the diastereoselective addition of methyl organometallic compounds to the benzyl imine derived from conveniently protected D-glyceraldehyde in order to develop a new approach to enantiomerically pure alpha-hydroxy-beta-amino acids is reported. Methylmagnesium bromide addition afforded the corresponding adduct, which can be further elaborated to give (2S, 3R) 3-amino-2-hydroxybutanoic acid, with complete diastereoselectivity.

引用

页码：529 / 536

页数：8

共 45 条

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