NSDNA: a manually curated database of experimentally supported ncRNAs associated with nervous system diseases

被引：39

作者：

Wang, Jianjian ^{[1
]}

Cao, Yuze ^{[1
]}

Zhang, Huixue ^{[1
]}

Wang, Tianfeng ^{[1
]}

Tian, Qinghua ^{[1
]}

Lu, Xiaoyu ^{[1
]}

Lu, Xiaoyan ^{[1
]}

Kong, Xiaotong ^{[1
]}

Liu, Zhaojun ^{[1
]}

Wang, Ning ^{[1
]}

Zhang, Shuai ^{[1
]}

Ma, Heping ^{[2
]}

Ning, Shangwei ^{[3
]}

Wang, Lihua ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Neurol, Affiliated Hosp 2, Harbin 150081, Peoples R China

[2] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA 30322 USA

[3] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin 150081, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

NONCODING RNAS; LONG; RESOURCE; MICRORNA; V2.0;

D O I：

10.1093/nar/gkw1038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Nervous System Disease NcRNAome Atlas (NSDNA) (http://www.bio-bigdata.net/nsdna/) is a manually curated database that provides comprehensive experimentally supported associations about nervous system diseases (NSDs) and noncoding RNAs (ncRNAs). NSDs represent a common group of disorders, some of which are characterized by high morbidity and disabilities. The pathogenesis of NSDs at the molecular level remains poorly understood. ncRNAs are a large family of functionally important RNA molecules. Increasing evidence shows that diverse ncRNAs play a critical role in various NSDs. Mining and summarizing NSD-ncRNA association data can help researchers discover useful information. Hence, we developed an NSDNA database that documents 24 713 associations between 142 NSDs and 8593 ncRNAs in 11 species, curated from more than 1300 articles. This database provides a user-friendly interface for browsing and searching and allows for data downloading flexibility. In addition, NSDNA offers a submission page for researchers to submit novel NSD-ncRNA associations. It represents an extremely useful and valuable resource for researchers who seek to understand the functions and molecular mechanisms of ncRNA involved in NSDs.

引用

页码：D902 / D907

页数：6

共 32 条

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