Forskolin studies

被引：20

作者：

Behnke, D

Hennig, L

Findeisen, M

Welzel, P

Müller, D

Thormann, M

Hofmann, HJ

机构：

[1] Univ Leipzig, Fak Chem & Mineral, D-04103 Leipzig, Germany

[2] Ruhr Univ Bochum, Fak Chem, D-44780 Bochum, Germany

[3] Univ Leipzig, Inst Biochem, D-04103 Leipzig, Germany

来源：

TETRAHEDRON | 2000年 / 56卷 / 08期

关键词：

nucleophilic isoprenoid C-5 reagent; forskolin intermediate; adenylyl cyclase;

D O I：

10.1016/S0040-4020(00)00005-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new nucleophilic isoprenoid C-5 reagent is introduced which allowed synthesis of an advanced and optically active forskolin intermediate in a very efficient way. In addition, docking experiments that are based on X-ray results indicate that there might exist forskolin analogues with improved properties as far as binding to adenylyl cyclases and synthetic accessibility are concerned. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1081 / 1095

页数：15

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