Comparative study of reductive amination reaction on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the Multipin™ approach

被引：7

作者：

Bui, CT ^{[1
]}

Bray, AM ^{[1
]}

Pham, Y ^{[1
]}

Campbell, R ^{[1
]}

Ercole, F ^{[1
]}

Rasoul, FA ^{[1
]}

Maeji, NJ ^{[1
]}

机构：

[1] Chiron Technol Pty Ltd, Clayton, Vic 3168, Australia

来源：

MOLECULAR DIVERSITY | 1998年 / 4卷 / 03期

关键词：

linkers; N-alkylamides; reductive amination; solid-phase synthesis;

D O I：

10.1023/A:1009642429617

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid (Barany) linker and its monomethoxy analog were applied to the Multipin(TM) method of solid phase synthesis. A comparative assessment of reductive amination and cleavage of these linkers under conditions of multiple synthesis indicated that both were applicable to a broad range of primary amines including aniline and 4-nitroaniline. Apart from the greater lability of the dimethoxy version under TFA cleavage, there was no observable advantage of one linker over the other within the described experiment.

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收藏

页码：155 / 163

页数：9

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