Two different and highly organized mechanisms of translation initiation in the archaeon Sulfolobus solfataricus

被引：103

作者：

Tolstrup, N

Sensen, CW

Garrett, RA

Clausen, IG

机构：

[1] Novo Nordisk AS, Enzyme Res, Bioinformat & DNA Sequencing, DK-2880 Bagsvaerd, Denmark

[2] Natl Res Council Canada, Inst Marine Biosci, Halifax, NS B3H 3Z1, Canada

[3] Inst Mol Biol, DK-1307 Copenhagen K, Denmark

来源：

EXTREMOPHILES | 2000年 / 4卷 / 03期

关键词：

Sulfolobus solfataricus; translation initiation; Shine-Dalgarno; transcription; crenarchaeota;

D O I：

10.1007/s007920070032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The translational starts of 144 Sulfolobus solfataricus genes have been determined by database comparison. Half the genes lie inside operons and the other half are at the start of an operon or single genes. A Shine-Dalgarno sequence is found upstream of the genes inside operons, but not for the first gene in an operon or isolated genes; this indicates that two different mechanisms are used for translation initiation in S, solfataricus. A box A transcriptional signal is found for the genes starting an operon or isolated genes, but not for the genes inside an operon. The box A signal is Located about 27nt upstream of the start codon, which implies that little or no upstream sequence is available for translation initiation for this group of genes. This finding is discussed.

引用

页码：175 / 179

页数：5

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