New and more potent antifungal disulfides

被引：20

作者：

Baerlocher, FJ

Baerlocher, MO

Langler, RF ^{[1
]}

MacQuarrie, SL

Marchand, ME

机构：

[1] Mt Allison Univ, Dept Biol, Sackville, NB E4L 1G7, Canada

[2] Mt Allison Univ, Dept Chem, Sackville, NB E4L 1G7, Canada

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2000年 / 53卷 / 01期

关键词：

antifungal; disulfides; structure-activity relationship; synthesis;

D O I：

10.1071/CH99139

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From a design principle described in an earlier paper, a new series of substituted aryl methyl disulfides have been prepared and tested against Aspergillus niger and Aspergillus flavus. Methyl p-nitrophenyl disulfide is more potent (by an order of magnitude) than the fungitoxic natural product (CH3SCH2S)(2). With the present rationale in hand, one can anticipate which Polycarpamine is an effective antifungal agent.

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页码：1 / 5

页数：5

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