Therapeutic potential of naringin in neurological disorders

被引：93

作者：

Ahmed, Salman ^{[1
]}

Khan, Haroon ^{[2
]}

Aschner, Michael ^{[3
]}

Hasan, Muhammad Mohtasheemul ^{[1
]}

Hassan, Sherif T. S. ^{[4
]}

机构：

[1] Univ Karachi, Fac Pharm & Pharmaceut Sci, Dept Pharmacognosy, Karachi 75270, Pakistan

[2] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan

[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA

[4] Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Nat Drugs, Brno, Czech Republic

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2019年 / 132卷

关键词：

Neuroprotective; Polyphenols; Naringin antiapoptotic; Antioxidant; Antineuroinflammation; NF-KAPPA-B; MITOCHONDRIA-MEDIATED APOPTOSIS; GRAPEFRUIT FLAVONOID NARINGENIN; ACID-INDUCED NEURODEGENERATION; OXIDATIVE STRESS; SIGNALING PATHWAY; IN-VITRO; COGNITIVE DYSFUNCTION; INDUCED OSTEOPOROSIS; POSSIBLE MECHANISMS;

D O I：

10.1016/j.fct.2019.110646

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Neurological illnesses are multifactorial incurable debilitating disorders that may cause neurodegeneration. These diseases influence approximately 30 million people around the world. Despite several therapies, effective management of such disorders remains a global challenge. Thus, natural products might offer an alternative therapy for the treatment of various neurological disorders. Polyphenols, such as curcumin, resveratrol, myricetin, mangiferin and naringin (NRG) have been shown to possess promising potential in the treatment of neurogenerative illness. In this review, we have targeted the therapeutic potential of naringin as a neuroprotective agent. The overall neuroprotective effects and different possible underlying mechanisms related to NRG are discussed. In light of the strong evidence for the neuropharmacological efficacy of NRG in various experimental paradigms, it is concluded that this molecule should be further considered and studied as a potential candidate for neurotherapeutics, focusing on mechanistic and clinical trials to ascertain its efficacy.

引用

页数：12

共 134 条

[61]

Lithium Inhibits GSK3β Activity via Two Different Signaling Pathways in Neurons After Spinal Cord Injury [J].