The Continuous-Flow Synthesis of Ibuprofen

被引：221

作者：

Bogdan, Andrew R. ^{[2
]}

Poe, Sarah L. ^{[2
]}

Kubis, Daniel C. ^{[2
]}

Broadwater, Steven J. ^{[2
]}

McQuade, D. Tyler ^{[1
]}

机构：

[1] Florida State Univ, Chem Sci Lab, Dept Chem & Biochem, Tallahassee, FL 32306 USA

[2] Cornell Univ, Baker Lab, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 45期

基金：

美国国家科学基金会;

关键词：

continuous processing; flow chemistry; microreactors; reactor design; synthetic methods; ORGANIC-SYNTHESIS; MULTISTEP SYNTHESIS; COUPLING REACTIONS; REACTORS; CHEMISTRY; MECHANISM; CATALYSIS; ACYLATION;

D O I：

10.1002/anie.200903055

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Let relief flow forth I A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8547 / 8550

页数：4

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